| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Secreted virulence factors and immune evasion in visceral leishmaniasis | |
| 关键词: macrophage; phosphatase; kinase; protein secretion; exosomes; vaccine; | |
| DOI : 10.1189/jlb.0611326 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Evasionorsubversionofhostimmuneresponsesisawell‐establishedparadigmininfectionwithvisceralizingleishmania.Inthisreview,wesummarizecurrentfindingssupportingamodelinwhichleishmaniatargethostregulatorymoleculesandpathways,suchasthePTPSHP‐1andthePI3K/Aktsignalingcascade,topreventeffectivemacrophageactivation.Furthermore,wedescribehowvirulencefactors,secretedbyleishmania,interferewithmacrophageintracellularsignaling.Finally,wediscussmechanismsofsecretionandprovideevidencethatleishmaniausearemarkablyadept,exosome‐basedsecretionmechanismtoexportanddelivereffectormoleculestohostcells.Inadditiontorepresentinganovelmechanismfortraffickingofvirulencefactorsacrossmembranes,recentfindingsindicatethatleishmaniaexosomesmayhavepotentialasvaccinecandidates...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904041509822ZK.pdf | 996KB |  download |
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