Influence Of Some Dissolution Enhancing Agents On The Pharmacokinetic Profile Of Meloxicam Delivered From Hydrophilic Ointments

Current Health Sciences Journal

Ani-Simona Sevastrereplacement¹ 

关键词: Meloxicam;    ointments;    Franz diffusion cell;    enhancers;   

DOI  :  10.12865/CHSJ.36.03.09

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Meloxicam, a very poorly soluble in water selective COX2 non steroidian antiinflamatory drug, was included in Carbopol 990 hydrogels using dissolution enhancing agents. Carbopol 990 is a high molecular weight polymer, easily soluble in water even at low concentrations, with increased viscosity, transparency and filmogen gel forming properties. To increase the solubility of Meloxicam, in this study we used Tween 80, Triethanolamine and polyethylene glycol 400 (PEG 400). The kinetic profile of Meloxicam in vitro release from pharmaceutical formulations was studied using Franz diffusion cell. Methylcellulose artificial membrane was used as diffusion membrane.

【 授权许可】

Unknown