Loading and Release of Doxorubicin with Magnetic Nanotubes#

Bulletin of the Korean Chemical Society

Sang Bok Lee¹  Douglas English²  Xiang Wang³  Xia Bai³ 

[1] 0051 USA;Department of Chemistry Wichita State University Wichita KS 67260‐Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA

关键词: Magnetic nanotubes;    Superparamagnetic iron oxide nanoparticles;    Doxorubicin;    pH‐;    dependent controlled release;    Encapsulation;    Degradation;   

DOI  :  10.1002/bkcs.10141

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In this work, we study magnetic nanotubes (MNTs) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18‐silane and pyridine–silane. By tuning the interaction between the drug molecules and inner surfaces of MNTs via pH, Dox can be effectively encapsulated at pH 7.2 and released at pH 4.5. The successful loading of Dox is confirmed with confocal microscopy studies. The release profiles of Dox from modified MNTs are detected by spectrofluorophotometry, with bare MNTs as control. With proper modifications, MNTs can be used for pH‐dependent, controlled release of drug molecules.

【 授权许可】

Unknown