Ultrasonic-mediated catalyst-free rapid protocol for the multicomponent synthesis of dihydroquinoline derivatives in aqueous media

Green Chemistry Letters and Reviews

Ramakanth Pagadala¹ 

关键词: ultrasound;    multicomponent reaction (MCR);    dihydroquinoline derivatives;    water as a solvent;    catalyst-free;    green chemistry;   

DOI  :  10.1080/17518253.2014.902505

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Catalyst-free multicomponent protocol for the condensation of malononitrile, 2-naphthol/resorcinol, aldehydes, and ammonium acetate in aqueous medium under ultrasound irradiation at 60oC afforded a wide range of valuable dihydroquinolines in high yields (90–97%) with short reaction times (60–90 min). This approach offers vital improvements for the synthesis of target compounds with regard to yield of products, simplicity in operation, utilization of water as solvent, and green aspects by avoiding the catalysts or solvents.

【 授权许可】

Unknown