MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids

Organics

Didier Villemin¹  Bernard Moreau¹  Nathalie Bar¹ 

[1] Normandie Université, France, ENSICAEN, LCMT, UMR CNRS 6507, INC3M, FR 3038, Labex EMC3, Labex SynOrg, 14050 Caen, France;

关键词: multicomponent reaction (MCR);    aminophosphonic acetic acid;    green conditions;    microwave irradiation;   

DOI  :  10.3390/org2020009

来源: DOAJ

【 摘 要 】

Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this reaction is more sensitive to steric hindrance of amine than the similar Kabachnik–Fields reaction. Amino acids can be also transformed into the expected bis(2-phosphonoacetic) acids, with the exception of tryptophan, which gives a β-carboline product.

【 授权许可】

Unknown