Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis

International Journal of Clinical and Experimental Pathology

Yingtian Wang¹ 

关键词: Radiation pneumonitis;    transforming growth factor;    meta-analysis;    polymorphism;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Background: The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. Methods: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Results: There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR = 1.77; 95% CI, 1.27-2.47; P = 0.0007). Conclusion: This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.

【 授权许可】

CC BY-NC