Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis

International Journal of Molecular Sciences

Su Kang Kim³  Sang Wook Kang³  Joo-Ho Chung³  Hae Jeong Park³  Kyu Bong Cho²  Min-Su Park¹ 

[1] Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130-702, Korea;Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University, Gyeonggi 480-701, Korea; E-Mail:;Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea; E-Mails:

关键词: glutathione S-transferase enzymes;    polymorphism;    schizophrenia;    meta-analysis;   

DOI  :  10.3390/ijms160819602

来源: mdpi

【 摘 要 】

The association between polymorphisms of glutathione-related enzyme (GST) genes and the risk of schizophrenia has been investigated in many published studies. However, their results were inconclusive. Therefore, we performed a meta-analysis to explore the association between the GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of schizophrenia. Twelve case-control studies were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Our meta-analysis results revealed that GSTM1, GSTT1, and GSTP1 polymorphisms were not related to risk of schizophrenia (p > 0.05 in each model). Further analyses based on ethnicity, GSTM polymorphism showed weak association with schizophrenia in East Asian population (OR = 1.314, 95% CI = 1.025–1.684, p = 0.031). In conclusion, our meta-analysis indicated the GSTM1 polymorphism may be the only genetic risk factor for schizophrenia in East Asian population. However, more meta-analysis with a larger sample size were needed to provide more precise evidence.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.