Microwave-assisted ammonium formate-mediated Knoevenagel reaction under solvent-free conditions – a green method for C–C bond formation

Green Chemistry Letters and Reviews

Manabendra Saha¹ 

关键词: alkenes;    ammonium salts;    microwave heating;    solvent-free reaction;    solid-phase synthesis;   

DOI  :  10.1080/17518250802141200

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Syntheses of structurally varied densely functionalized olefins have been accomplished (23 examples) through microwave-assisted ammonium formate-mediated Knoevenagel condensation of differently substituted aromatic aldehydes with ethyl cyanoacetate, cyanoacetamide, malononitrile, and malonic acid under solvent-free condition in good yield (76–95%) and high purity. The said reactions occur within very short period of time (0.75–3 min) in eco-friendly conditions involving an operationally simple procedure, eliminating any kind of inorganic support, toxic reagent and organic solvent.

【 授权许可】

Unknown