The crystal structures of three clozapinium salts: different mol­ecular configurations, and supra­molecular assembly in one, two and three dimensions

Acta Crystallographica Section E: Crystallographic Communications

Jasinski, J.P.¹  Yathirajan, H.S.²  Kaur, M.²  Kavitha, C.N.²  Glidewell, C.³ 

[1] Department of Chemistry, Keene State College, 229 Main Street, Keene, NH 03435-2001, USA;Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India;School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, Scotland

关键词: CRYSTAL STRUCTURE;    CLOZAPINIUM;    CRYSTAL STRUCTURE;    MOLECULAR CONFIGURATION;    HYDROGEN BONDING;    SUPRAMOLECULAR ASSEMBLY;   

DOI  :  10.1107/S205698901500554X

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The structures of three salts derived from clozapine, 8-chloro-11-(4-methyl­piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, are reported, namely, clo­za­pin­ium 3,5-di­nitro­benzoate dimethyl sulfoxide monosolvate, C18H20ClN4+·C7H3N2O6−·C2H6OS, (I), where the dimethyl sulfoxide component is disordered over two sets of atomic sites having occupancies 0.627 (2) and 0.373 (2); clo­za­pin­ium hydrogen maleate 0.21-hydrate, C18H20ClN4+·C4H3O4−·0.21H2O, (II), and clozapinium 2-hy­droxy­benzoate, C18H20ClN4+·C7H5O3−, (III). In all three salts, the protonation site is the methyl­ated N atom of the piperazine ring, and the dimensions and conformations of the fused tricyclic system are very similar. However, differences are apparent in the piperazine component: in both compounds (II) and (III), the unprotonated N atom of this ring has a pyramidal geometry, but in compound (I) this atom has a planar geometry. In compound (III), both N-substituents in this ring occupy equatorial sites, but in compound (II) the fused tricyclic system occupies an axial site of the piperazine ring. The independent components of compound (I) are linked within the selected asymmetric unit by a combination of N—H⋯O and C—H⋯O hydrogen bonds, and these hydrogen-bonded aggregates are linked into chains by an aromatic π–π stacking inter­action. In compound (II), the components are linked into sheets by a combination of O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds, and in compound (III), a combination of N—H⋯O, C—H⋯O and C—H⋯N hydrogen bonds links the components into a three-dimensional framework structure. Comparisons are made with some similar compounds.

【 授权许可】

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