The Discovery of Novel Protein Tyrosine Phosphatase ε Inhibitors Using a High‐throughput Screening Approach

Bulletin of the Korean Chemical Society

Seung Jun Kim¹  Bonsu Ku²  Chul Shin²  Yeoung Yun³  Ho‐³  Chang Hyen Kim⁴  Beom Park⁵  Hye‐⁵  Hye Seon Lee⁵  Jun‐⁵ 

[1] 701 Republic of Korea;Analytical Science University of Science and Technology Daejeon 34113 Republic of Korea;Department of Bio‐Department of Periodontics, Seoul St Mary's Hospital The Catholic University of Korea Seoul 137‐Disease Target Structure Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Republic of Korea

关键词: Protein tyrosine phosphatase;    High‐;    throughput screening;    Chemical library;    Inhibitor;    Osteoporosis;   

DOI  :  10.1002/bkcs.11044

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Protein tyrosine phosphatase epsilon (PTPε) is important for signal transduction in osteoclasts, and is considered to be an attractive drug target for the treatment of osteoporosis. We identified 11 potent PTPε inhibitors based on three chemical scaffolds through the high‐throughput screening of a chemical library. As these compounds are structurally diverse with high bioavailability, they warrant further investigation in the near future. The discovery of these inhibitors and the relationship between their structure and inhibitory activity toward PTPε is discussed in detail.

【 授权许可】

Unknown