Bulletin of the Korean Chemical Society | |
Protection Effect of Cyanidin 3‐O‐Glucoside Against Oxidative Stress‐induced HepG2 Cell Death Through Activation of Akt and Extracellular Signal‐regulated Kinase Pathways | |
Jun Yeon Park1  Ki Sung Kang1  Hae‐2  | |
[1] College of Korean Medicine Gachon University Seongnam 13120 Korea;Department of Food and Nutrition, College of BioNano Technology Gachon University Seongnam 13120 Korea | |
关键词: Cyanidin 3‐; O‐; glucoside; Tertiary butyl hydroperoxide; Extracellular signal‐; regulated kinases; Akt; | |
DOI : 10.1002/bkcs.11290 | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
The attack of reactive oxygen species (ROS) on unsaturated fatty acids causes peroxidation. The membranes of liver cells are rich in unsaturated fatty acids, which are a target of lipid peroxidation by free radicals. The purpose of the present study was to identify the hepatoprotective potential of Lonicera caerulea and its active compound, cyanidin 3âOâglucoside, on tertiary butyl hydroperoxide (tBHP)âinduced oxidative damage in HepG2 cells. L. caerulea extract and its active compound, cyanidin 3âOâglucoside, showed a doseâdependent hepatoprotective effect on tBHPâinduced HepG2 cell damage. In addition, L. caerulea and cyanidin 3âOâglucoside inhibited the production of intracellular ROS in tBHPâtreated HepG2 cells. The protein expression of phosphorylatedâextracellular signalâregulated kinases and Akt, which are responsible for cell protection against ROS, were increased after treatment with cyanidin 3âOâglucoside (50 and 100 μM) in a doseâdependent manner. Therefore, cyanidin 3âOâglucoside is the active compound in L. caerulea, which is responsible for the hepatoprotective effects through the inhibition of ROS and the activation of antioxidant mechanisms.
【 授权许可】
Unknown
【 预 览 】
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