Electrostatic and Functional Analysis of the Seven-Bladed WD β-Propellers

Evolutionary Bioinformatics

Najl V Valeyev¹ 

关键词: β-propeller;    electrostatics;    evolutionary trace;    protein clustering;    WD protein;   

DOI  :  10.4137/EBO.S743

学科分类：生物技术

来源: Sage Journals

【 摘 要 】

β-propeller domains composed of WD repeats are highly ubiquitous and typically used as multi-site docking platforms to coordinate and integrate the activities of groups of proteins. Here, we have used extensive homology modelling of the WD40–repeat family of seven-bladed β-propellers coupled with subsequent structural classification and clustering of these models to define subfamilies of β-propellers with common structural, and probable, functional characteristics. We show that it is possible to assign seven-bladed WD β-propeller proteins into functionally different groups based on the information gained from homology modelling. We examine general structural diversity within the WD40-repeat family of seven-bladed β-propellers and demonstrate that seven-bladed β-propellers composed of WD-repeats are structurally distinct from other seven-bladed β-propellers. We further provide some insights into the multifunctional diversity of the seven-bladed WD β-propeller surfaces. This report once again reinforces the importance of structural data and the usefulness of homology models in functional classification.

【 授权许可】

Unknown