A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”

Viruses

Katherine R. Hargreaves¹  Martha R. J. Clokie¹ 

[1] Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire LE1 9HN, UK; E-Mail:

关键词: bacteriophage;    Clostridium difficile;    taxonomy;    protein clustering;    Siphoviridae;    Myoviridae;    small myovirus;    bacteriophage phylogeny;   

DOI  :  10.3390/v7052534

来源: mdpi

【 摘 要 】

Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus “phicd119likevirus”. An additional nine phages have since been described in the literature with their genome data available. The Phicd119likevirus is named after the type species: the myovirus ΦCD119 which was the first C. difficile phage to be sequenced. The two additional myoviruses, ϕCD27 and φC2, also fall into this genus based on the similarity of their genome and morphological characteristics. The other nine phages have not been assigned to this genus, and four of them do not fit the criteria for the current taxonomic grouping. We have applied protein clustering analysis to determine their phylogenetic relationships. From these results we propose an additional myoviridae genus, that we term “phiMMP04likevirus”.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.