Self‐assembling Helical Rod–Coil Peptoid Amphiphiles

Bulletin of the Korean Chemical Society

Young Deok Ahn¹  Yen Jea Lee¹  Jiwon Seo¹  Boyeong Kang¹  Solchan Chung²  Jae Young Lee² 

[1] Department of Chemistry, School of Physics and Chemistry Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea;School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea

关键词: Peptoid;    Amphiphile;    Self‐;    assembly;    Water‐;    soluble peptoid;    Porphyrin–;    peptoid conjugates;   

DOI  :  10.1002/bkcs.11042

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A helical rod–coil motif was employed to design water‐soluble peptoid amphiphiles. Prior to this study, this approach was rarely exploited in the construction of amphiphilic peptoids. The helical rod–coil motif enabled complete dissolution of the peptoids 1 and 2 in water. The critical micelle concentration (CMC) of the water‐soluble peptoids was measured. Circular dichroism (CD) analysis of each peptoid was performed to confirm the helical secondary structure in solution. Scanning electron microscopy (SEM) revealed the surface morphology of the self‐assembled peptoid structures. Water‐soluble peptoids comprised helical rod–coil structures provide a variety of self‐assembled architectures in aqueous solutions.

【 授权许可】

Unknown