Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Cellular Physiology and Biochemistry

关键词: TSLP;    DCs;    Th17 inflammation;    Atherosclerosis;   

DOI  :  10.1159/000343369

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis. However, the mechanism underlying Th17 inflammation in atherosclerosis remains largely unknown. Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine and mainly responsible for Th2 inflammation in many inflammatory diseases. Methods and Results Immunohistochemistry showed that TSLP over-expressed in human atherosclerotic lesion and could be induced by ox-LDL in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs). TSLP, in turn, could activate dendritic cells (DCs) to differentiate Th17 inflammation in naive CD4⁺ T cells. Conclusion TSLP induced by ox-LDL could promote Th17 immune response in vitro, which may be implicated in Th17 inflammation in atherosclerosis.

【 授权许可】

CC BY-NC-ND