A facile and efficient synthesis of tri- and tetrasubstituted imidazoles with potassium hydrogen sulfate and DB18C6 in an aqueous medium

Green Chemistry Letters and Reviews

Chhanda Mukhopadhyay¹ 

关键词: potassium hydrogen sulfate;    DB18C6;    tri- and tetrasubstituted imidazoles;    aqueous medium;    green reaction conditions;   

DOI  :  10.1080/17518253.2011.584572

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Potassium hydrogen sulfate in the presence of dibenzo-18-crown-6 (DB18C6) turns out to be a very efficient and effective catalyst for the facile synthesis of a wide variety of tri- and tetrasubstituted imidazoles in an aqueous medium at moderate temperature. The idea behind this is that the potassium ion, being trapped in the crown core, frees the hydrogen sulfate anion, which, because of its acidic nature, succeeds in the ready synthesis of the imidazoles.

【 授权许可】

Unknown