Diversification of Indoles via Microwave‐assisted Ligand‐free Copper‐catalyzed N‐Arylation

Bulletin of the Korean Chemical Society

Eul Kgun Yum¹  Jae‐²  Kwan Kwon²  Jin ‐²  Hee Lee²  Tae Sung Kim³ 

[1] 750 Korea;Department of Chemistry Chungnam National University Daejon 34134 Korea;Western Seoul Center Korea Basic Science Institute Seoul 120‐

关键词: Microwave;    Ligand‐;    free;    ;    Cu2O ;    Indole;    N‐;    arylation;   

DOI  :  10.1002/bkcs.10995

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A simple, efficient Cu2O catalyst system under microwave irradiation was developed for N‐arylation of various indoles without ligands and additives. Diverse N‐heteroarylated indoles were prepared by coupling indoles with various heteroaryl halides within 1 h. The selective reactivity of bromoindole with aryl iodide provided N‐aryl bromoindoles, which could be useful intermediates for palladium‐catalyzed Heck and Suzuki coupling reactions.

【 授权许可】

Unknown