Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method

Evolutionary Bioinformatics

Abdelmonaem Messaoudi¹ 

关键词: comparative homology modeling;    protein modeling;    bioinformatics;    lipase enzymes;   

DOI  :  10.4137/EBO.S7122

学科分类：生物技术

来源: Sage Journals

【 摘 要 】

Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a template for model building. This model was then assessed for stereochemical quality and side chain environment. Natural substrates: tributyrin, trioctanoin and triolen were docked into the model to investigate ligand-substrate interaction.

【 授权许可】

Unknown