PROFASA—a web-based protein fragment and structure analysis workstation

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Venkata V. B. Yallapragada¹  Stefan-Bogdan Marcu²  Sabin Tabirca³  Yanlin Mi⁴ 

[1] Centre for Advanced Photonics and Process Analytics, Munster Technological University, Cork, Ireland;Tyndall National Institute, Cork, Ireland;School of Computer Science and Information Technology, University College Cork, Cork, Ireland;School of Computer Science and Information Technology, University College Cork, Cork, Ireland;Faculty of Mathematics and Informatics, Transylvania University of Brasov, Brasov, Romania;School of Computer Science and Information Technology, University College Cork, Cork, Ireland;SFI Centre for Research Training in Artificial Intelligence, University College Cork, Cork, Ireland;

关键词: protein modeling;    computational biology;    proteins;    edutainment;    gamification;    molecular visualisation;    bioinformatics;   

DOI  :  10.3389/fbioe.2023.1192094

 received in 2023-03-22, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: In the field of bioinformatics and computational biology, protein structure modelling and analysis is a crucial aspect. However, most existing tools require a high degree of technical expertise and lack a user-friendly interface. To address this problem, we developed a protein workstation called PROFASA.Methods: PROFASA is an innovative protein workstation that combines state-of-the-art protein structure visualisation techniques with cutting-edge tools and algorithms for protein analysis. Our goal is to provide users with a comprehensive platform for all protein sequence and structure analyses. PROFASA is designed with the idea of simplifying complex protein analysis workflows into one-click operations, while providing powerful customisation options to meet the needs of professional users.Results: PROFASA provides a one-stop solution that enables users to perform protein structure evaluation, parametric analysis and protein visualisation. Users can use I-TASSER or AlphaFold2 to construct protein models with one click, generate new protein sequences, models, and calculate protein parameters. In addition, PROFASA offers features such as real-time collaboration, note sharing, and shared projects, making it an ideal tool for researchers and teaching professionals.Discussion: PROFASA’s innovation lies in its user-friendly interface and one-stop solution. It not only lowers the barrier to entry for protein computation, analysis and visualisation tools, but also opens up new possibilities for protein research and education. We expect PROFASA to advance the study of protein design and engineering and open up new research areas.

【 授权许可】

Unknown   
Copyright © 2023 Mi, Marcu, Tabirca and Yallapragada.