Ventricular Remodeling Induced by Tissue Vitamin A Deficiency in Rats

Cellular Physiology and Biochemistry

关键词: Inflammation;    Oxidative stress;    Energetic metabolism;    Vitamin A;    Remodeling;   

DOI  :  10.1159/000320563

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background/Aims Experimental studies suggest that vitamin A plays a role in regulating cardiac structure and function. We tested the hypothesis that cardiac vitamin A deficiency is associated with adverse myocardial remodeling in young adult rats. Methods Two groups of young female rats, control (C - n = 29) and tissue vitamin A deficient (RVA - n = 31), were subjected to transthoracic echocardiography exam, isolated rat heart study and biochemical study. Results The RVA rats showed a reduced total vitamin A concentration in both the liver and heart [vitamin A in heart, µmol/kg (C = 0.95 ± 0.44 and RVA = 0.24 ± 0.16, p = 0.01)] with the same serum retinol levels (C = 0.73 ± 0.29 µmol/L e RVA = 0.62 ± 0.17 µmol/L, p = 0.34). The RVA rats showed higher left ventricular diameters and reduced systolic function. The RVA rats also demonstrated increased lipid hydroperoxide/total antioxidant capacity ratio and cardiac levels of IFN-γ and TNF-α but not of metalloproteinase (MMP)-2 and -9 activity. On the other hand, the RVA rats had decreased levels of β-hydroxyacylcoenzyme A dehydrogenase and lactate dehydrogenase. Conclusions Tissue vitamin A deficiency stimulated cardiac remodeling and ventricular dysfunction. Additionally, the data support the involvement of oxidative stress, energy metabolism, and cytokine production in this remodeling process.

【 授权许可】

CC BY-NC-ND