Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism : a cross -sectional study

BMC Pulmonary Medicine

Research Article

Sung-Ok Kwon¹  Se-Young Oh¹  Young-Ho Jung²  Soo-Jong Hong³  Eun Lee³  Bong-Seong Kim⁴  Song-I Yang⁵  So-Yeon Lee⁵  Hae-Ran Lee⁵  Ju-Hee Seo⁶  Hyung Young Kim⁷  Hyo-Bin Kim⁸  Ji-Won Kwon⁹  Hye Lim Shin^1,10 

[1] Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul, South Korea;Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Yatap-dong Bundang-gu, 463-712, Seongnam, Gyeonggido, South Korea;Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, 138-736, Songpa-gu, Seoul, South Korea;Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea;Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, 39, Gwanpyeong-ro 138 beon-gil, 431-828, Dongan-gu, Anyang, Gyeonggido, South Korea;Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea;Department of Pediatrics, Kosin University Gospel Hospital, Busan, South Korea;Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea;Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea;Research Center for Standardization of Allergic Diseases, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea;

关键词: Asthma;    Vitamin A;    Antioxidant;    Environmental tobacco smoke;    Oxidative stress;    Polymorphism;   

DOI  :  10.1186/s12890-015-0093-0

 received in 2014-08-11, accepted in 2015-08-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAsthma is characterized by airway inflammation, and bronchial airways are particularly susceptible to oxidant-induced tissue damage.ObjectiveTo investigate the effect of dietary antioxidant intake and environmental tobacco smoke (ETS) on the risk of childhood asthma according to genotypes susceptible to airway diseases.MethodsThis cross-sectional study included 1124 elementary school children aged 7–12 years old. Asthma symptoms and smoking history were measured using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Intake of vitamin A (including retinol and β-carotene), C, and E was measured by a semi-quantitative food frequency questionnaire (FFQ). GSTP1 polymorphisms were genotyped from peripheral blood samples.ResultsETS was significantly associated with presence of asthma symptoms (adjusted odds ratio [aOR], 2.48; 95 % confidence interval [CI], 1.29–4.76) and diagnosis (aOR, 1.91; 95 % CI, 1.19–3.06). Dietary antioxidant intake was not associated with asthma symptoms, although ETS plus low vitamin A intake showed a significant positive association with asthma diagnosis (aOR, 2.23; 95 % CI, 1.10–4.54). Children with AA at nucleotide 1695 in GSTP1 who had been exposed to ETS and a low vitamin A intake have an increased risk of asthma diagnosis (aOR, 4.44; 95 % CI,1.58–12.52) compared with children who had not been exposed to the two risk factors. However, ETS exposure and low vitamin A intake did not significantly increase odds of asthma diagnosis in children with AG or GG genotypes.ConclusionLow vitamin A intake and ETS exposure may increase oxidative stress and thereby risk for childhood asthma. These relationships may be modified by gene susceptibility alleles of GSTP1.

【 授权许可】

CC BY   
© Lee et al. 2015