Polysaccharides As Viscosupplementation Agents: Structural Molecular Characteristics but Not Rheology Appear Crucial to the Therapeutic Response

Frontiers in Medicine

Rita C. Machado¹ 

关键词: viscosupplementation;    hyaluronic acid;    polysaccharide;    osteoarthritis;    pain;    cartilage;    guar gum;   

DOI  :  10.3389/fmed.2017.00082

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

IntroductionMost clinical studies and basic research document viscosupplementation (VS) in terms of effectiveness and safety, but only a few highlight its molecular mechanisms of action. Besides, there is generally focus on hyaluronic acid (HA) as being the most relevant polysaccharide to reach the clinical endpoints, attributing its effect mainly to its unique viscoelastic properties, related to a high-molecular weight and gel formulation. Usually, studies do not approach the possible biological pathways where HA may interfere, and there is a lack of reports on other biocompatible polysaccharides that could be of use in VS.

【 授权许可】

CC BY