Long-term Outcomes of Childhood Onset Nephrotic Syndrome

Frontiers in Pediatrics

Rebecca Hjorten¹ 

关键词: nephrotic syndrome;    children;    pediatric;    outcomes;    genetics;    focal glomerulosclerosis;    minimal-change disease;   

DOI  :  10.3389/fped.2016.00053

学科分类：儿科学

来源: Frontiers

【 摘 要 】

There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

【 授权许可】

CC BY