Cardiac and vascular complications of Behçet disease in the Tunisian context: clinical characteristics and predictive factors

Advances in Rheumatology

Ines Khochtali¹  Melek Kechida¹  Sonia Hammami¹  Rim Klii¹  Rim Kahloun²  Sana Salah³ 

[1] Internal Medicine and Endocrinology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia;Ophtalmology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia;Physical Medicine and Rehabilitaion Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia

关键词: Behcet syndrome;    Cardiovascular system;    Risk factors;   

DOI  :  10.1186/s42358-018-0032-x

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

Cardiac and vascular involvement in Behçet disease (BD), also referred as vasculo BD, is frequent. We aimed to describe clinical characteristics, predictive factors and management of vasculo BD in the Tunisian context. We retrospectively studied 213 records of all BD patients followed between January 2004 and May 2016 in the Internal Medicine Department and who fulfilled the ISGBD criteria. We described first clinical features of BD with cardiac and vascular involvement then predictive factors were studied in univariate then multivariate analysis. Among the 213 patients, 64 (30%) were diagnosed as having vasculo BD. The mean age at diagnosis was 31.5 years. About 81.25% of them were males and 18.75% females. Vascular involvement associated or not with cardiac involvement was found in 64 patients (30%). Deep venous thromboses are most common (62.5%) compared with superficial ones (23.4%), pulmonary arterial thrombosis (14.1%) or aneurysms (9.4%). Cardiac involvement is ranging from pericarditis (1.6%) to intra cardiac thrombosis (3.1%) and myocardial infarction (1.6%). Predictive factors associated with cardiac and vascular involvement in BD are male gender (OR = 3.043, 95% CI = 1.436–6.447, p = 0.004), erythema nodosum (OR = 4.134, 95% CI = 1.541–11.091, p = 0.005) and neurologic involvement (OR = 2.46, 95% CI = 1.02–5.89, p = 0.043). Cardiac and vascular involvement in BD is frequent in the Tunisian context with a broad spectrum of manifestations ranging from vascular involvement to cardiac one. Male gender, patients with erythema nodosum or neurologic involvement are prone to develop cardiac or vascular features of BD needing therefore a close monitoring.

【 授权许可】

CC BY