pH responsive MMT/Acrylamide Super Composite Hydrogel: Characterization, Anticancer Drug Reservoir and Controlled Release Property - Composite hydrogel:Drug Delivery

Biochemistry and Biophysics

Bhavesh D. Kevadiya¹ 

关键词: Composite Hydrogel;    Biomarkers;    Cytotoxicity;    Pharmacokinetics;    Na+-MMT;   

DOI  :  

学科分类：生物化学/生物物理

来源: Science and Engineering Publishing Company

【 摘 要 】

Abstract: We report here, the preparation and characterization of polyacrylamide/Na+-MMT (Montmorillonite) composite hydrogels and its application as anticancer drug carrier reservoir. The X-ray diffraction patterns, thermal and spectroscopic analyses indicate that the acrylamide andMMT has been successfully conglomerated to form composite gels. The degree of swelling was higher in composite hydrogels as compared to pristine hydrogel; and the hydrophilic MMT improved the water absorbing properties of composite hydrogels. The mode of water transport in the composite hydrogels was partially through a swollen polymeric matrix and water filling in clay layers of the composite hydrogels. In vitro drug release studydemonstrated the controlled release pattern. In vitro cytotoxicity of drug loaded composite hydrogel was evaluated in MCF-7 and Hela cells by MTT assay. In vivo pharmacokinetics, biodistribution, toxicity biomarkers and total serum protein analysis were also investigated after single oral administration of drug in rats.

【 授权许可】

Unknown