Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis

PLoS One

Heinrich Sauer¹  Kerstin Langbein²  Magdalena Holub²  Ingrid Holzer²  Claudia M. Klier³  Michael Berk⁴  Patrick D. McGorry⁴  Miriam R. Schäfer⁵  Christine Milleit⁵  Monika Schlögelhofer⁵  Uta-Christina Hipler⁵  G. Paul Amminger⁶  Stefan Smesny⁷  Berko Milleit⁷  Gregor E. Berger⁸ 

[1] Deakin University of Melbourne, School of Medicine, Barwon Health, Geelong, Australia;Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18–20, A–1090 Vienna, Austria;Department of Dermatology, University Hospital Jena, Erfurter Straße 35, D-07743 Jena, Germany;Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria;Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany;Florey Institute for Neuroscience and Mental Health, Parkville, Australia;Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia;University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland

关键词: Niacin;    Schizophrenia;    Fatty acids;    Psychoses;    Lipids;    Prostaglandin;    Membrane metabolism;    Skin tests;   

DOI  :  10.1371/journal.pone.0148429

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders. Methods We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics. Results Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling. Conclusions Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a “pro-inflammatory state”, whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.

【 授权许可】

CC BY