Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History

PLoS One

the PEPs Group¹  Antonio Lobo¹  Miguel Bernardo²  Manuel J. Cuesta²  Bibiana Cabrera²  Susana Alberich²  Celso Arango²  Ana González-Pinto²  Ana M. Sánchez-Torres³  Itxaso González-Ortega⁴  Sonia Ruiz de Azúa⁴  Iluminada Corripio⁴  Miquel Bioque⁴ 

[1] Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain;Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain;Department of Psychiatry and Clinical Psychobiology, University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;Department of Psychiatry, Araba University Hospital, University of the Basque Country, Vitoria, Spain

关键词: Cannabis;    Cognitive impairment;    Psychoses;    Cognitive psychology;    Drug users;    Cognition;    Working memory;    Memory;   

DOI  :  10.1371/journal.pone.0160949

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.

【 授权许可】

CC BY