Number of Risky Lifestyle Behaviors and Breast Cancer Risk

JNCI Cancer Spectrum

Tretli, Steinar¹  Russnes, Hege G²  Hjartåker, Anette³  Ursin, Giske⁴  Ellingjord-Dale, Merete⁵  Vik Hjerkind, Kirsti⁵  Vos, Linda⁵  Hofvind, Solveig⁵  dos-Santos-Silva, Isabel⁵ 

[1] Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;Department of Pathology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;Department of nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Department of radiography and dental technology, Oslo and Akershus University College of Applied Sciences, Oslo, Norway;Department of research, Cancer Registry of Norway, Oslo, Norway

关键词: body mass index procedure;    life style;    phenobarbital;    breast cancer;    breast cancer risk;    smoking;    physical activity;    breast cancer, luminal a subtype;    estrogen replacement therapy;    genes, erbb-2;    receptor, erbb-2;    her2 positive;    menopause;    her2 negative;    her-2 positive breast cancer;    gravidity;    menarche;    eyeglasses;   

DOI  :  10.1093/jncics/pky030

学科分类：肿瘤学

来源: Oxford University Press

【 摘 要 】

BackgroundLifestyle factors are associated with overall breast cancer risk, but less is known about their associations, alone or jointly, with risk of specific breast cancer subtypes.MethodsWe conducted a case–control subjects study nested within a cohort of women who participated in the Norwegian Breast Cancer Screening Program during 2006–2014 to examine associations between risky lifestyle factors and breast cancer risk. In all, 4402 breast cancer cases subjects with information on risk factors and hormone receptor status were identified. Conditional logistic regression was used to estimate odds ratios (ORs), with 95% confidence intervals (CIs), in relation to five risky lifestyle factors: body mass index (BMI) of 25 kg/m² or greater, three or more glasses of alcoholic beverages per week, ever smoking, fewer than four hours of physical activity per week, and ever use of menopausal hormone therapy. Analyses were adjusted for education, age at menarche, number of pregnancies, and menopausal status. All statistical tests were two-sided.ResultsCompared with women with no risky lifestyle behaviors, those with five had 85% (OR = 1.85, 95% CI = 1.42 to 2.42, Ptrend < .0001) increased risk of breast cancer overall. This association was limited to luminal A–like (OR = 2.20, 95% CI = 1.55 to 3.12, Ptrend < .0001) and luminal B–like human epidermal growth factor receptor 2 (HER2)–positive (OR = 1.66, 95% CI = 0.61 to 4.54, Ptrend < .004) subtypes. Number of risky lifestyle factors was not associated with increased risk of luminal B–like HER2-negative, HER2-positive, or triple-negative subtypes (Ptrend > .18 for all).ConclusionsNumber of risky lifestyle factors was positively associated with increased risk for luminal A–like and luminal B–like HER2-positive breast cancer.

【 授权许可】

CC BY-NC-ND