Influences of the Common FTO rs9939609 Variant on Inflammatory Markers Throughout a Broad Range of Body Mass Index

PLoS One

Arne Astrup¹  David M. Hougaard¹  Torben Hansen²  Tine Jess³  Thorkild I. A. Sørensen⁴  Oluf Pedersen⁴  Kristin Skogstrand⁵  Esther Zimmermann⁶ 

[1] Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark;Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark;Faculty of Health Science, University of Aarhus, Aarhus, Denmark;Hagedorn Research Institute, Gentofte, Denmark;Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark;Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark

关键词: Obesity;    Body mass index;    Inflammation;    Leptin;    Inflammatory diseases;    Adipokines;    Genotyping;    Regression analysis;   

DOI  :  10.1371/journal.pone.0015958

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background A recent study reported that the fatness associated A-allele of FTO rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness. We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish men. Methodology/Principal Findings In a population of 362,200 young men, examined for military service between 1943 and 1977, two groups were identified: 1) a random 1% sample and 2) all obese men (BMI = 31.0 kg/m2, all of whom were above the 99th percentile of this population). At an average age of 49 years (range: 39 through 65 years), 551 men, hereof 231 of the obese, were re-examined, including genotyping and measurement of the fasting circulating inflammatory markers hs-CRP, IL-1β, IL-6, IL-10, IL-18, mip1α, mip1β, sTNFα-R1, TGF-β, TNF-α and leptin. Men with known disease were excluded from the examination. All the inflammatory markers were log-transformed to approximate a normal distribution. Genotype-phenotype relationships were studied using linear regression analyses with the inflammatory markers as the response variable. Significant positive associations between hs-CRP, leptin and a broad range of BMI were observed, but the associations did not significantly differ across FTO rs9939609 genotype. There were no significant associations between the other inflammatory markers, FTO rs9939609 genotype or BMI, respectively. Conclusion No fatness-independent effects of the FTO rs9939609 A-allele on a series of inflammatory markers were observed in this cohort of healthy middle-aged men representing a broad range of fatness.

【 授权许可】

CC BY