Parkinson’s disease-associated protein Parkin: an unusual player in cancer

Cancer Communications

Zhaohui Feng¹  Juan Liu²  Wenwei Hu²  Cen Zhang² 

[1] Department of Pharmacology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA;Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA

关键词: Parkin;    Parkinson’s disease;    Cancer;    E3 ubiquitin ligase;    Tumor suppressor;   

DOI  :  10.1186/s40880-018-0314-z

学科分类：肿瘤学

来源: Springer

【 摘 要 】

The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.

【 授权许可】

CC BY