POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiation:

European Journal of Inflammation

M KemalOzbilgin¹ 

关键词: bladder;    histochemistry;    immunohistochemistry;    proopiomelanocortin;    urothelium;   

DOI  :  10.1177/1721727X15624698

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC expression in the urothelium during radiation injury.Methods:Twenty-four male Swiss Albino mice were divided into four groups. A single-fractioned 10 Gy of ionizing radiation was applied to the pelvic zone of all mice with Cobalt-60 radiotherapy. The first group 1, which consisted intact animal and not irradiated was the control group, and the second, third, and fourth groups were euthanized after 24 h (Group 2), 48 h (Group 3), and 7 days (Group 4) after irradiation. All bladders were prepared for his...

【 授权许可】

CC BY-NC