Kartogenin: A Novel Cell Free Treatment Modality for Tendon-Bone Junction Injuries

Foot & Ankle Orthopaedics

JianyingZhang¹ 

关键词: Kartogenin;    Tendon-bone junction;    Achilles Tendon;    Fibrocartilage Zone;    Chondrogenesis;    Platelet-Rich Plasma (PRP);   

DOI  :  10.1177/2473011416S00214

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:Tendon-bone junction (TBJ) injuries are very common and optimal treatment modalities are lacking. TBJ injuries often heal without formation of the fibrocartilage transition zone increasing the risk of rerupture. Current treatments only attach tendons to bones but do not promote healing or regeneration of the fibrocartilage zone. Therefore, we developed a novel approach to heal wounded TBJ using a small molecule called kartogenin (KGN). KGN was previously shown to induce chondrogenesis of tendon stem/progenitor cells (TSCs) in vitro and enhance wound healing in injured rat TBJs in vivo after short- term treatment (2 weeks). It is not known whether these effects can be maintained longterm. Therefore, we studied the long term (3 months) effects of KGN on achilles-tendon-bone junction healing.Methods:KGN stock was prepared in DMSO and diluted to 100 μM with PRP solution. PRP was obtained from the blood of Sprague–Dawley rats and the platelet concentration ...

【 授权许可】

CC BY