Kartogenin Enhances Tendon Graft And Bone Tunnel Healing In A Rat Model:

Foot & Ankle Orthopaedics

Yiqin ZhouZhou¹ 

关键词: Kartogenin;    Tendon-Bone Junction;    Platelet-Rich Plasma (PRP);    Fibrocartilage Zone;    Achilles tendon;   

DOI  :  10.1177/2473011416S00213

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:The normal tendon-bone junction (TBJ) is a strong structure protected by the fibrocartilage transition zone. This allows a gradual transition of mechanical forces between tendon and bone, thus decreasing stress-concentration effects. Healing of the TBJ interface after an injury is slow and even after healing the junction often lacks the transition zone. A study on human patients showed that even years after ACL reconstruction, patients had no fibrocartilage zone regeneration. This and other studies show that surgical repair alone does not restore the unique protective fibrocartilage transition zone. We have shown that KGN injection into injured rat Achilles tendon-bone junctions enhanced wound healing with restored fibrocartilage transition zone. Here, we examined the effects of KGN treatment, along with platelet-rich plasma (PRP), on tendon-bone tunnel healing in rats.Methods:KGN stock was prepared in DMSO and diluted to 100 μM with PRP. PRP was obtai...

【 授权许可】

CC BY