Journal of Evidence-Based Integrative Medicine | |
Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats: | |
SaeedSamarghandian1  | |
关键词: Portulaca oleracea; diabetes; rat; streptozotocin; oxidative indices; inflammation; | |
DOI : 10.1177/2156587217692491 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)–treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured. STZ caused an elevation in the serum levels of glucose, MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS (P < .01). Portulaca oleracea ameliorated glucose, MDA, IL-6, TNF-α, GSH, and TAS levels in diabetic groups versus to the untreated groups (P < .05). Taken together, Portulaca oleracea prevented hyperglycemia by preventing the oxidative stress and inflammation.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201904027224542ZK.pdf | 181KB | download |