Aging-like physiological changes in the skin of Japanese obese diabetic patients:

SAGE Open Medicine

AiIbuki¹ 

关键词: Skin physiology;    skin structure;    skin barrier;    aging;    obese-diabetes;   

DOI  :  10.1177/2050312118756662

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:Obesity-associated diabetes causes aging-like changes to skin physiology in animal models, but there have been no clinical studies focusing on human obese diabetic patients. The purpose of this study was to examine the hypothesis that obesity-associated diabetes accelerates aging-like skin changes in Japanese people.Methods:This cross-sectional study enrolled obese-diabetes patients (body mass index ≥ 25 kg m−2) and healthy volunteers (body mass index < 25 kg m−2) as controls. Skin physiology parameters relating to aging (stratum corneum hydration, transepidermal water loss, skin pH, advanced glycation end-products, and dermal collagen density) were evaluated in the two groups.Results:About 37 subjects participated (16 in a control group and 21 in an obese-diabetes group). Age was not significantly different between the groups. The stratum corneum hydration level was significantly lower in the obese-diabetes group. Transepidermal water loss and levels of advanced glycation end-products were sign...

【 授权许可】

CC BY