Radiotherapy for gynecologic cancer in nonagenarian patients: a framework for new paradigms

Cancer Communications

Sophie Espenel¹  Benoî¹  Anaï¹  Olivier Collard¹  Pierre Auberdiac¹  Alexis Vallard¹  Romain Rivoirard¹  Jean-Baptiste Guy²  s Valeille³  Guy de Laroche⁴  ry⁴  Avi Assouline⁴  Alexander T. Falk⁴  Guillaume Moriceau⁴  Trone⁴  te Mé⁴  Jane-Chloé⁴  Sylvie Mengue Ndong⁵  Claire Bosacki⁶  Jean-Philippe Jacquin⁷ 

[1] Department of Medical Oncology, Lucien Neuwirth Cancer Institute, Saint Priest En Jarez, France;Department of Radiation Oncology, Antoine Lacassagne Center, Nice, France;Department of Radiotherapy, Claude Bernard Private Hospital, Albi, France;Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint Priest En Jarez, France;Department of Radiotherapy, Porte De Saint Cloud Clinical Center, Boulogne-Billancourt, France;Department of Radiotherapy, Val-De-Grâce Military Hospital, Paris, France

关键词: Gynecologic cancer;    Nonagenarians;    Female genital tract;    Radiotherapy;    Geriatrics;   

DOI  :  10.1186/s40880-016-0104-4

学科分类：肿瘤学

来源: Springer

【 摘 要 】

No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian patients. We retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer (6 endometrial cancers, 6 cervical cancers, 4 vulvar cancers, and 3 vaginal cancers) who were treated with radiotherapy. Radiotherapy was performed mainly in a palliative setting (n = 12; 63.2%), with a median dose of 45 Gy (range, 6–76 Gy). Infrequent major acute or late toxicities were reported. Among 19 patients, 9 (47.4%) experienced tumor progression, 5 (26.3%) experienced complete response, 2 (10.5%) experienced stable disease and/or partial response. At last follow-up, 12 patients (63.2%) had died; most deaths (n = 9) occurred because of the cancer. These results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

【 授权许可】

CC BY