Tryptophan Transport in Human Fibroblast Cells—A Functional Characterization:

International Journal of Tryptophan Research

RaviVumma¹ 

关键词: fibroblasts;    tryptophan;    serotonin;    LAT1;    amino acid transporters;   

DOI  :  10.4137/IJTR.S6913

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

There are indications that serotonergic neurotransmission is disturbed in several psychiatric disorders. One explanation may be disturbed transport of tryptophan (precursor for serotonin synthesis) across cell membranes. Human fibroblast cells offer an advantageous model to study the transport of amino acids across cell membranes, since they are easy to propagate and the environmental factors can be controlled. The aim of this study was to functionally characterize tryptophan transport and to identify the main transporters of tryptophan in fibroblast cell lines from healthy controls.

【 授权许可】

CC BY