The Axonal Guidance Receptor Neogenin Promotes Acute Inflammation

PLoS One

Peter Rosenberger¹  Dimitra Gatidou¹  Tiago Granja²  Valbona Mirakaj²  Klemens König²  Jens Meier² 

[1] Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University Tübingen, Tübingen, Germany

关键词: Inflammation;    Peritoneal lavage;    Intraperitoneal injections;    Peritonitis;    Central nervous system;    Cytokines;    Histology;    Fats;   

DOI  :  10.1371/journal.pone.0032145

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Neuronal guidance proteins (NGP) were originally described in the context of axonal growth and migration. Yet recent work has demonstrated that NGPs also serve as guidance cues for immune competent cells. A crucial target receptor for NGPs during embryonic development is the neogenin receptor, however its role during acute inflammation is unknown. We report here that neogenin is abundantly expressed outside the nervous system and that animals with endogenous repression of neogenin (Neo1−/−) demonstrate attenuated changes of acute inflammation. Studies using functional inhibition of neogenin resulted in a significant attenuation of inflammatory peritonitis. In studies employing bone marrow chimeric animals we found the hematopoietic presence of Neo1−/− to be responsible for the attenuated inflammatory response. Taken together our studies suggest that the guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.

【 授权许可】

CC BY