Higher Leptin but Not Human Milk Macronutrient Concentration Distinguishes Normal-Weight from Obese Mothers at 1-Month Postpartum

PLoS One

Régis Hankard¹  Pierre Ingrand²  Marie-Agnès Gaud³  Clair-Yves Boquien³  Arnaud De Luca⁴  Richard J. Robins⁵  Manon Herviou⁶  Dominique Darmaun⁶  Marine Frasquet-Darrieux⁷  Patricia Christin⁸  Christine Millet⁸ 

[1] Centre de Recherche en Nutrition Humaine Ouest, Nantes, France;INRA UMR 1280, Institut des Maladies de l’Appareil Digestif, University Hospital of Nantes, Nantes, France;INSERM CIC 1402, Poitiers, France;INSERM U 1069, Tours, France;Maternity, General Hospital of Chatellerault, Chatellerault, France;Pediatrics-Child Nutrition, University Hospital of Poitiers, Poitiers, France;University Hospital of Tours, Tours, France;University of Poitiers, Poitiers, France

关键词: Leptin;    Obesity;    Breast milk;    Infants;    Body mass index;    Milk;    Breast feeding;    Weight gain;   

DOI  :  10.1371/journal.pone.0168568

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Introduction Exclusively breastfed infants born to obese mothers have previously been shown to gain less weight by 1-month postpartum than infants of normal-weight mothers. Our hypothesis is that human milk composition and volume may differ between obese and normal-weight mothers. Objective To compare human milk leptin, macronutrient concentration, and volume in obese and normal-weight mothers. Mother and infant characteristics were studied as secondary aims. Materials and Methods This cross-sectional observational study compared 50 obese mothers matched for age, parity, ethnic origin, and educational level with 50 normal-weight mothers. Leptin, macronutrient human milk concentration, and milk volume were determined at 1 month in exclusively breastfed infants. Mother characteristics and infant growth were recorded. Results Human milk leptin concentration was higher in obese mothers than normal-weight mothers (4.8±2.7 vs. 2.5±1.5 ng.mL-1, p<0.001). No difference was observed between obese and normal-weight mothers in protein, lipid, carbohydrate content, and volume, nor in infant weight gain. Conclusion Leptin concentration was higher in the milk of obese mothers than that of normal-weight mothers, but macronutrient concentration was not. It remains to be established whether the higher leptin content impacts on infant growth beyond the 1-month of the study period.

【 授权许可】

CC BY