Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization:

Innate Immunity

ArjunBalakrishnan¹ 

关键词: Bactericidal/permeability increasing protein (BPI);    antimicrobial peptides;    PLUNC proteins;    endotoxic shock;    Gram-negative bacteria;   

DOI  :  10.1177/1753425912465098

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Bactericidal permeability increasing protein (BPI), a 55–60 kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.

【 授权许可】

CC BY