Proceedings of Singapore Healthcare | |
Should Chemotherapy Be Administered for Essential Thrombocythemia (ET) Patients with Leukemic Transformation?: | |
Gee ChuanWong1  | |
关键词: BCR-ABL negative; blasts; induction; | |
DOI : 10.1177/201010581102000107 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Introduction:Essential Thrombocythemia (ET) is a clonal myeloproliferative disease presenting predominantly with thrombocytosis. One of its rare complications is leukemic transformation (LT). Once leukemic transformation occurs, prognosis is dismal. We aim to determine the disease profile of LT in our ET patients and evaluate if chemotherapy can alter prognosis.Methods:Clinical data of all patients diagnosed and treated with ET from 1999 to 2008 in the Department of Hematology, Singapore General Hospital, were captured in the Myeloproliferative Disease(MPD) Registry. ET patients with LT were selected. Patient characteristics, disease profile, including ET treatment, duration from ET diagnosis to LT, prior myelofibrosis (MF) history, type of chemotherapy, response and eventual survival were recorded.Results:Two hundred and thirty ET patients were diagnosed and treated from 1999 to 2008. Six patients had LT (2.6%). All were Chinese. Four were females. Age range was 47–70 years (mean 61.2 years). Transformat...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201904025504095ZK.pdf | 453KB | download |