Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats:

Journal of Evidence-Based Integrative Medicine

Ayoola I.Olushola¹ 

关键词: high salt–fed rat;    Persea americana;    lactate dehydrogenase;    nitric oxide;    sodium ion;    potassium ion;   

DOI  :  10.1177/2156587217733884

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background.The cardioprotective effects of Persea americana extract was investigated on biochemical activities of high salt–fed adult Wistar rats in this study.Method.Forty healthy Wistar rats of both sexes weighing 120 to 150 g were randomly assigned into 8 groups of 5 rats each (groups A, B, C, D, E, F, G, and H). Rats in groups A, F, G, and H were fed with standard laboratory pellets, while groups B, C, D, and E were fed on the high-salt diet for 4 weeks. Concomitantly, daily administration of 50, 100, and 150 mg/kg of the P americana extract were given orally to groups C and F, D and G, and E and H, respectively, while rats in groups A and B were administered distilled water. Blood samples were taken by cardiac puncture; concentration of sodium ion, potassium ion, nitric oxide, and activity of lactate dehydrogenase were determined. One-way analysis of variance was used to analyze data, followed by Student-Newman-Keuls (SNK) test for multiple comparison.Results.Results revealed that concentration of po...

【 授权许可】

CC BY-NC