期刊论文详细信息
Frontiers in Medicine | |
Cell Autofluorescence and Lipofuscin | |
Giovanni Di Guardo1  | |
关键词: autofluorescence; lipofuscin; lipofuscin-like substances; stem cells; epithelial cancer stem cells; cancer stem cells; | |
DOI : 10.3389/fmed.2015.00006 | |
学科分类:医学(综合) | |
来源: Frontiers | |
【 摘 要 】
I was greatly impressed by an article recently published in Nature Methods (1), in which intracellular autofluorescence was characterized as a biomarker for epithelial cancer stem cells (CSCs). Interestingly, this epithelial CSC-specific autofluorescence was also associated with a highly invasive and chemoresistant phenotype. Riboflavin (vitamin B2) – an ABCG2-selectively transported substrate – was identified, after autophagy had been ruled out, as the source of cell autofluorescence (1).
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201904024829326ZK.pdf | 224KB | download |