Cell Autofluorescence and Lipofuscin

Frontiers in Medicine

Giovanni Di Guardo¹ 

关键词: autofluorescence;    lipofuscin;    lipofuscin-like substances;    stem cells;    epithelial cancer stem cells;    cancer stem cells;   

DOI  :  10.3389/fmed.2015.00006

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

I was greatly impressed by an article recently published in Nature Methods (1), in which intracellular autofluorescence was characterized as a biomarker for epithelial cancer stem cells (CSCs). Interestingly, this epithelial CSC-specific autofluorescence was also associated with a highly invasive and chemoresistant phenotype. Riboflavin (vitamin B2) – an ABCG2-selectively transported substrate – was identified, after autophagy had been ruled out, as the source of cell autofluorescence (1).

【 授权许可】

CC BY