Macrophage Phagocytosis and Allergen Avoidance in Children With Asthma

Frontiers in Pediatrics

Neeta Kulkarni¹ 

关键词: macrophages;    phagocytosis;    asthma;    children;    allergen avoidance;   

DOI  :  10.3389/fped.2018.00206

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Background and Objective: Airway macrophages perform the crucial functions of presenting antigens, clearing pathogens, and apoptotic cells. Macrophage phagocytosis is increased in adults with mild asthma and allergen exposure is known to activate macrophages. However, it is not clear whether the mechanism behind this is due to a primary defect or environmental factors such as allergen or lipopolysaccaride (LPS) exposure. Our aim was to assess the phagocytic function of airway macrophages in children with mild to moderate asthma after residence in a low allergen\LPS environment at high altitude.

【 授权许可】

CC BY