Analisi di Farmacoutilizzazione dei Trattamenti Biologici Nelle Malattie Infiammatorie Immunomediate Croniche: I Risultati di Uno Studio Osservazionale Retrospettivo Condotto in un Centro Ospedaliero del Centro Italia:

Global & Regional Health Technology Assessment

PaoloFaccendini¹ 

关键词: Dose escalation;    Dose modification;    Dose tapering;    Drug utilization;    IMID;   

DOI  :  10.5301/grhta.5000271

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Drug utilization of biological drugs in the treatment of chronic Immune-Mediated Inflammatory Diseases (IMIDs): an observational study on Italian patientsObjectivesThe aim of this analysis was to provide an estimate of drug utilization indicators (dose escalation and dose tapering) related to biologic drugs in the chronic treatment of adult patients with Immune-Mediated Inflammatory Diseases (IMIDs).MethodsWe conducted an observational retrospective cohort analysis using the Policlinico di Tor Vergata (PTV) database. We considered all biologic drugs dispensed by the PTV hospital pharmacy between January 2010 and December 2015:abatacept, adalimumab, certolizumab, etanercept, golimumab, infliximab (originator and biosimilar), tocilizumab, and ustekinumab were included. Drug dose escalation and dose tapering were calculated and compared with their Defined Daily Dose (DDD).ResultsA total of 1803 patients with IMID and biologic drug prescription were analyzed (male: 51.2%). The majority of patients were in the...

【 授权许可】

CC BY