РОЛЬ НАРУШЕНИЙ СИНТЕЗА ПРОГЕСТЕРОНА И ЕГО ПРОИЗВОДНЫХ В РАЗВИТИИ НЕВРОЛОГИЧЕСКИХ РАССТРОЙСТВ У ДЕТЕЙ ПРИ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИИ ВО ВРЕМЯ БЕРЕМЕННОСТИ

Acta Biomedica Scientifica

М. Т. Луценко¹  И. Н. Гориков¹  Н. А. Ишутина¹  И. В. Довжикова¹  И. А. Андриевская¹  С. В. Медведева² 

[1] ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»;ФГБОУ ВО «Амурская государственная медицинская академия» Минздрава РФ

关键词: цитомегаловирусная инфекция;    плацента;    беременность;    прогестерон;    5-дигидропрогестерон;    аллопрегненолон;    новорождённые;   

DOI  :  10.29413/ABS.2018-3.4.12

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral  agent causing an imbalance in the production of placenta  progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was to evaluate the concentration  of progesterone and its metabolites – 5α-dihydroprogesterone and  allopregnenolone – in placenta during exacerbation of CMV infection  in the first trimester of pregnancy, and the impact of these  disturbances on the development of neurological disorders in children. We examined 30 pregnant women with exacerbation of  CMV infection in the first trimester of pregnancy and 30 pregnant  women with latent disease; and later their newborns. The enzyme  immunoassay was used to determine  concentration of progesterone  in placenta; the histochemical method – to determine 5α-dihydroprogesterone and allopregnenolone. Newborns underwent  neurosonography studies. Exacerbation of CMV infection in the first  trimester of pregnancy decreased progesterone in placenta by 1.3  times, 5α-dihydroprogesterone – by 1.73 times and allopregnenolone – by 2 times. Ultrasound examination of the brain  showed ventriculomegaly, periventricular ischemia, and pseudocysts  in newborns up to one year from mothers with exacerbation of CMV  during pregnancy. Later, minimal brain dysfunctions were manifested by motor disorders, increased general, vegetative excitability, and a  tendency to digestive and sleep disorders. The data obtained  indicate that the exacerbation of CMV infection in the first trimester  of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns.

【 授权许可】

CC BY