ВЗАИМОСВЯЗЬ ИЗМЕНЕНИЙ КОНЦЕНТРАЦИИ ЛЕПТИНА И КИСЛОТ ω-3 СЕМЕЙСТВА В ПЛАЦЕНТЕ ПРИ РЕАКТИВАЦИИ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИИ В III ТРИМЕСТРЕ ГЕСТАЦИИ

Acta Biomedica Scientifica

М. Т. Луценко¹  Н. Н. Дорофиенко¹  Н. А. Ишутина¹  И. А. Андриевская¹ 

[1] ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»

关键词: лептин;    эйкозапентаеновая кислота;    докозагексаеновая кислота;    плацента;    цитомегаловирусная инфекция;   

DOI  :  10.12737/article_59fad5100b9ac7.30669050

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

A gas-chromatographic study was conducted of the content of essential polyunsaturated fatty acids of the ω-3 family: eicosapentaenoic and docosahexaenoic, an enzyme-linked immunosorbent assay of leptinin the homogenate of placental tissue in women who during the third trimester of gestation (32 weeks) underwent reactivation of chronic cytomegalovirus infection with an antibody titer Immunoglobulin class G to cytomegalovirus 1:1600. The main group of studies was 42 placentas taken from women with cytomegalovirus infection during the period of labor. The obtained data were compared with similar parameters of the control group, which included 35 placental tissues of practically healthy women in childbirth. Based on the analysis of the data obtained, it was found that the reactivation of chronic cytomegalovirus infection in the third trimester of pregnancy (32 weeks) is associated with decrease in the concentration of ω-3 essential polyunsaturated fatty acids: eicosapentaenoic by 23 % (р < 0.01) and docosahexaenoic by 42 % (р < 0.001) with a simultaneous increase in the concentration of leptin in the placental tissue by 61 % (р < 0.001). In these conditions, the mechanisms of regulation of the transmission of fatty acids from the peripheral blood of the mother to the blood of the developing fetus through the placenta are disrupted. The contents of leptin during pregnancy is an important indicator that carries information not only about the energy reserves of the maternal organism, but also about the state of the fe^lacental complex.

【 授权许可】

CC BY