Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid–Induced Colitis in Rats:

Journal of Evidence-Based Integrative Medicine

AmirRashidian¹ 

关键词: Ocimum basilicum;    myeloperoxidase;    volatile constituents;    acetic acid;    colitis;    traditional medicine;   

DOI  :  10.1177/2156587215616550

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Ocimum basilicum L has been traditionally used for the treatment of inflammatory bowel disease in Iran. This study investigates the ameliorative effect of Ocimum basilicum essential oil on an acetic acid–induced colitis model in rats. Ocimum basilicum essential oil with 2 doses (200 and 400 μL/kg) significantly ameliorated wet weight/length ratio of colonic tissue compared to the control group. Higher doses of essential oil (200 and 400 μL/kg) significantly reduced ulcer severity, ulcer area, and ulcer index. On the other hand, histological examination revealed the diminution of total colitis index as a marker for inflammatory cell infiltration in the colonic segments of rats treated with Ocimum basilicum essential oil (200 and 400 μL/kg). The increased level of myeloperoxidase was significantly decreased after the treatment with the essential oil (200 and 400 μL/kg). These results suggest that Ocimum basilicum exhibits protective effect against acetic acid–induced colitis.

【 授权许可】

CC BY-NC