Adipokines in rheumatoid arthritis

Advances in Rheumatology

Flvia Troncon Rosa¹  Isaias Dichi²  Andra Name Colado Simo³  Elis Carolina de Souza Fatel⁴ 

[1] Department of Nutrition, University of Fronteira Sul, Realeza, Brazil;Department of Pathology, Clinical Analysis and Toxicology, University Londrina, Londrina, Brazil;Postgraduate Program, Experimental Pathology, State University of Londrina, Londrina, Brazil;Postgraduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil

关键词: Adipokines;    Rheumatoid arthritis;    Cytokines;   

DOI  :  10.1186/s42358-018-0026-8

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

【 授权许可】

CC BY